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I do not believe that every person, in every walk of life, can succeed in spite of any handicap.
in spite of：虽然；不管；不顾；纵使
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招待自己的灵魂 Two Commandments Are Enough
佩吉·伍德/Peggy Wood
Occasionally my mother used to announce that she was going to take time out from the day's activities “to rest”, she would say, “and to invite my soul.”She always put the phrase in quotes, in order, I expect, to divert the facetious remarks which might arise from the worldly or practical-minded folk within earshot or to disarm those who might feel“soul”was a Sunday word not to be used in everyday conversation.